Abriendo la compuerta para el entendimiento del Dolor (Ronald Melzack, Patrick D. Wall-1965)

The quest to acquire knowledge and understanding of pain has had crucial moments in which the evolution of the process has been dramatically changed. These moments have been revelations that have opened the path to rethinking previously accepted knowledge and created new horizons of research, understanding and treatment. When Melzack and Wall first described what would come to be known as the “Gate Control theory” they were able not only to clarify basic aspects of pain development but to lead the way to further basic and clinical research studies. The psychological aspects, the clinical basis and the structural anatomical and physiological components created one of the most complete theories in medical sciences and the ground for the basic management of pain. It has been fifty years since the original article was published in Science magazine (Pain Mechanism: a new theory. A gate control system modulates sensory input from the skin before it evokes pain perception and response. Ronald Melzack and Patrick Wall. Science. November 19, 1965 volume 150, number 3699). It has been recognized even until today as the most cited reference in medical journals in the past 50 years. The paper was written during a very particular moment in scientific history and the context of two very different lives, which illustrates the incredible process that leads to scientific development. The analysis of what this paper has symbolized to pain science must be done not only from a purely scientific viewpoint but from a human one as well.