TY - JOUR
T1 - A theoretical model of dentinogenesis
T2 - Dentin and dentinal tubule formation
AU - Niño-Barrera, Javier L.
AU - Gutiérrez, María L.
AU - Garzón-Alvarado, Diego A.
PY - 2013/10
Y1 - 2013/10
N2 - Introduction: Dentinogenesis, odontoblast dentin formation, includes dentinal growth, mineralization and dentinal tubule formation. Odontoblasts synthesize collagen resulting in collagen apposition contributing to dentinogenesis. Furthermore, within the tubule, they express non-collagenous proteins, such as dentin phosphoprotein (DPP), associated with hydroxyapatite crystal formation and growth. The aim of this work was to determine patterns of growth and dentin formation and quantification of its mineralization. Findings from our work are relevant to endodontics for future regenerative treatment. Methods: We formulated a 3D domain mathematical model, which recreates the events that lead to dentinal tubule mineralization. As reference we used collagen apposition and DPP activity. Results: We obtained a model depicting predentin's mineralization distribution during dentin development. Furthermore, we verified different DPP diffusion coefficients to test the model's sensitivity. Conclusions: We present a model to shed light on the process of dentin and dentinal tubule formation, and its relation to diffusion and mineralization processes.
AB - Introduction: Dentinogenesis, odontoblast dentin formation, includes dentinal growth, mineralization and dentinal tubule formation. Odontoblasts synthesize collagen resulting in collagen apposition contributing to dentinogenesis. Furthermore, within the tubule, they express non-collagenous proteins, such as dentin phosphoprotein (DPP), associated with hydroxyapatite crystal formation and growth. The aim of this work was to determine patterns of growth and dentin formation and quantification of its mineralization. Findings from our work are relevant to endodontics for future regenerative treatment. Methods: We formulated a 3D domain mathematical model, which recreates the events that lead to dentinal tubule mineralization. As reference we used collagen apposition and DPP activity. Results: We obtained a model depicting predentin's mineralization distribution during dentin development. Furthermore, we verified different DPP diffusion coefficients to test the model's sensitivity. Conclusions: We present a model to shed light on the process of dentin and dentinal tubule formation, and its relation to diffusion and mineralization processes.
KW - Dentin
KW - Dentinal tubules
KW - Finite elements
KW - Mathematical modeling
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_puj3&SrcAuth=WosAPI&KeyUT=WOS:000324250400019&DestLinkType=FullRecord&DestApp=WOS_CPL
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-84883746328&origin=resultslist&sort=plf-f&src=s&sid=1a0a488622d1a571cb8a4f0d337d8bd8&sot=b&sdt=b&s=TITLE-ABS-KEY%28A+theoretical+model+of+dentinogenesis%3A+Dentin+and+dentinal+tubule+formation%29&sl=90&sessionSearchId=1a0a488622d1a571cb8a4f0d337d8bd8&relpos=0
U2 - 10.1016/j.cmpb.2013.06.010
DO - 10.1016/j.cmpb.2013.06.010
M3 - Article
C2 - 23866998
SN - 0169-2607
VL - 112
SP - 219
EP - 227
JO - Computer Methods and Programs in Biomedicine
JF - Computer Methods and Programs in Biomedicine
IS - 1
ER -