A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria

Manuel E. Patarroyo; Roberto Amador; Pedro Clavijo; Alberto Moreno; Fanny Guzman; Pedro Romero; Ricardo Tascon; Antonio Franco; Luis A. Murillo; Gabriel Ponton; Gustavo Trujillo

doi:10.1038/332158a0

A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria

Manuel E. Patarroyo
, Roberto Amador
, Pedro Clavijo
, Alberto Moreno
, Fanny Guzman
, Pedro Romero
, Ricardo Tascon
, Antonio Franco
, Luis A. Murillo
, Gabriel Ponton
, Gustavo Trujillo

Research output: Contribution to journal › Article › peer-review

351 Scopus citations

Abstract

We have previously shown that a mixture of three synthetic peptides (83.1, 55.1, 35.1), corresponding to fragments of the relative molecular mass 83,000 (83K), 55K and 35K Plasmodium falciparum merozoite-specific proteins, induces protection in Aotus trivirpatus monkeys experimentally infected with P. falciparum^1,2. Here we describe two polymeric synthetic hybrid proteins based on these peptides that delay or suppress the development of parasitaemia in immunized human volunteers.

Original language	English
Pages (from-to)	158-161
Number of pages	4
Journal	Nature
Volume	332
Issue number	6160
DOIs	https://doi.org/10.1038/332158a0
State	Published - 1988
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1038/332158a0

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title = "A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria",

abstract = "We have previously shown that a mixture of three synthetic peptides (83.1, 55.1, 35.1), corresponding to fragments of the relative molecular mass 83,000 (83K), 55K and 35K Plasmodium falciparum merozoite-specific proteins, induces protection in Aotus trivirpatus monkeys experimentally infected with P. falciparum1,2. Here we describe two polymeric synthetic hybrid proteins based on these peptides that delay or suppress the development of parasitaemia in immunized human volunteers.",

author = "Patarroyo, \{Manuel E.\} and Roberto Amador and Pedro Clavijo and Alberto Moreno and Fanny Guzman and Pedro Romero and Ricardo Tascon and Antonio Franco and Murillo, \{Luis A.\} and Gabriel Ponton and Gustavo Trujillo",

year = "1988",

doi = "10.1038/332158a0",

language = "English",

volume = "332",

pages = "158--161",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

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TY - JOUR

T1 - A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria

AU - Patarroyo, Manuel E.

AU - Amador, Roberto

AU - Clavijo, Pedro

AU - Moreno, Alberto

AU - Guzman, Fanny

AU - Romero, Pedro

AU - Tascon, Ricardo

AU - Franco, Antonio

AU - Murillo, Luis A.

AU - Ponton, Gabriel

AU - Trujillo, Gustavo

PY - 1988

Y1 - 1988

N2 - We have previously shown that a mixture of three synthetic peptides (83.1, 55.1, 35.1), corresponding to fragments of the relative molecular mass 83,000 (83K), 55K and 35K Plasmodium falciparum merozoite-specific proteins, induces protection in Aotus trivirpatus monkeys experimentally infected with P. falciparum1,2. Here we describe two polymeric synthetic hybrid proteins based on these peptides that delay or suppress the development of parasitaemia in immunized human volunteers.

AB - We have previously shown that a mixture of three synthetic peptides (83.1, 55.1, 35.1), corresponding to fragments of the relative molecular mass 83,000 (83K), 55K and 35K Plasmodium falciparum merozoite-specific proteins, induces protection in Aotus trivirpatus monkeys experimentally infected with P. falciparum1,2. Here we describe two polymeric synthetic hybrid proteins based on these peptides that delay or suppress the development of parasitaemia in immunized human volunteers.

UR - https://www.scopus.com/pages/publications/0023871934

U2 - 10.1038/332158a0

DO - 10.1038/332158a0

M3 - Article

C2 - 2450281

AN - SCOPUS:0023871934

SN - 0028-0836

VL - 332

SP - 158

EP - 161

JO - Nature

JF - Nature

IS - 6160

ER -

A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria

Abstract

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