TY - JOUR
T1 - A RICH AND COMPLEX DYNAMICS EMERGES BETWEEN THE SUBTHALAMIC NUCLEUS AND THE GLOBUS PALLIDUS EXTERNA IN THE BASAL GANGLIA
AU - Hurtado-López, Julián
AU - Amador-Rodriguez, Andres Felipe
AU - Ramirez-Moreno, David Fernando
N1 - Publisher Copyright:
© (2023), (Union Matematica Argentina). All Rights Reserved.
PY - 2023
Y1 - 2023
N2 - The oscillatory nature of basal ganglia activity is highly tied with some movement disorders. We study, through bifurcation analysis and computer simulations, the appearance of abnormal oscillations in an already proposed reduced neural circuit model of the subthalamic nucleus and globus pallidus loop. The results show that the model exhibits stable steady states associated to normal activity and oscillatory activity corresponding to the often termed “tremor frequency” oscillations due to their coherence with parkinsonian tremor observed in patients with Parkinson’s disease.
AB - The oscillatory nature of basal ganglia activity is highly tied with some movement disorders. We study, through bifurcation analysis and computer simulations, the appearance of abnormal oscillations in an already proposed reduced neural circuit model of the subthalamic nucleus and globus pallidus loop. The results show that the model exhibits stable steady states associated to normal activity and oscillatory activity corresponding to the often termed “tremor frequency” oscillations due to their coherence with parkinsonian tremor observed in patients with Parkinson’s disease.
KW - Bifurcation analysis
KW - Parkinson’s disease
KW - delta band
KW - globus pallidus externa
KW - oscillations
KW - subthalamic nucleus
UR - http://www.scopus.com/inward/record.url?scp=85177033723&partnerID=8YFLogxK
U2 - 10.33044/REVUMA.2893
DO - 10.33044/REVUMA.2893
M3 - Article
AN - SCOPUS:85177033723
SN - 0041-6932
VL - 64
SP - 397
EP - 412
JO - Revista de la Union Matematica Argentina
JF - Revista de la Union Matematica Argentina
IS - 2
ER -