TY - JOUR
T1 - A computational model of clavicle bone formation
T2 - A mechano-biochemical hypothesis
AU - Garzon-Alvarado, Diego A.
AU - Gutiérrez, María Lucía
AU - Calixto, Luis Fernando
PY - 2014/4
Y1 - 2014/4
N2 - Clavicle development arises from mesenchymal cells condensed as a cord extending from the acromion towards the sternal primordium. First two primary ossification centers form, extending to develop the body of the clavicle through intramembranous ossification. However, at its ends this same bone also displays endochondral ossification. So how can the clavicle be formed by both types of ossification? Developmental events associated with clavicle formation have mainly used histological studies as supporting evidence. Nonetheless, mechanisms of biological events such as molecular and mechanical effects remain to be determined.The objective of this work was to provide a mathematical explanation of embryological events based on two serial phases: first formation of an ossified matrix by intramembranous ossification based on three factors: systemic, local biochemical, and mechanical factors. After this initial phase expansion of the ossified matrix follows with mesenchymal cell differentiation into chondrocytes for posterior endochondral ossification. Our model provides strong evidence for clavicle formation integrating molecules and mechanical stimuli through partial differentiation equations using finite element analysis.
AB - Clavicle development arises from mesenchymal cells condensed as a cord extending from the acromion towards the sternal primordium. First two primary ossification centers form, extending to develop the body of the clavicle through intramembranous ossification. However, at its ends this same bone also displays endochondral ossification. So how can the clavicle be formed by both types of ossification? Developmental events associated with clavicle formation have mainly used histological studies as supporting evidence. Nonetheless, mechanisms of biological events such as molecular and mechanical effects remain to be determined.The objective of this work was to provide a mathematical explanation of embryological events based on two serial phases: first formation of an ossified matrix by intramembranous ossification based on three factors: systemic, local biochemical, and mechanical factors. After this initial phase expansion of the ossified matrix follows with mesenchymal cell differentiation into chondrocytes for posterior endochondral ossification. Our model provides strong evidence for clavicle formation integrating molecules and mechanical stimuli through partial differentiation equations using finite element analysis.
KW - Clavicle formation
KW - Finite elements analysis
KW - Reaction diffusion
KW - Turing pattern formation
UR - http://www.scopus.com/inward/record.url?scp=84893488018&partnerID=8YFLogxK
U2 - 10.1016/j.bone.2014.01.007
DO - 10.1016/j.bone.2014.01.007
M3 - Article
C2 - 24444803
AN - SCOPUS:84893488018
SN - 8756-3282
VL - 61
SP - 132
EP - 137
JO - Bone
JF - Bone
ER -