A computational model of clavicle bone formation: A mechano-biochemical hypothesis

Diego A. Garzon-Alvarado, María Lucía Gutiérrez, Luis Fernando Calixto

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Clavicle development arises from mesenchymal cells condensed as a cord extending from the acromion towards the sternal primordium. First two primary ossification centers form, extending to develop the body of the clavicle through intramembranous ossification. However, at its ends this same bone also displays endochondral ossification. So how can the clavicle be formed by both types of ossification? Developmental events associated with clavicle formation have mainly used histological studies as supporting evidence. Nonetheless, mechanisms of biological events such as molecular and mechanical effects remain to be determined.The objective of this work was to provide a mathematical explanation of embryological events based on two serial phases: first formation of an ossified matrix by intramembranous ossification based on three factors: systemic, local biochemical, and mechanical factors. After this initial phase expansion of the ossified matrix follows with mesenchymal cell differentiation into chondrocytes for posterior endochondral ossification. Our model provides strong evidence for clavicle formation integrating molecules and mechanical stimuli through partial differentiation equations using finite element analysis.

Original languageEnglish
Pages (from-to)132-137
Number of pages6
JournalBone
Volume61
DOIs
StatePublished - Apr 2014
Externally publishedYes

Keywords

  • Clavicle formation
  • Finite elements analysis
  • Reaction diffusion
  • Turing pattern formation

Fingerprint

Dive into the research topics of 'A computational model of clavicle bone formation: A mechano-biochemical hypothesis'. Together they form a unique fingerprint.

Cite this