α-Tocopherol loaded thermosensitive polymer nanoparticles: Preparation, in vitro release and antioxidant properties

Cirley Quintero; Ricardo Vera; Leon Dario Perez

doi:10.1590/0104-1428.2324

α-Tocopherol loaded thermosensitive polymer nanoparticles: Preparation, in vitro release and antioxidant properties

Cirley Quintero, Ricardo Vera, Leon Dario Perez

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

α-Tocopherol is the most bioavailable and active compound found in vitamin E with potential application in pharmaceutical, alimentary and cosmetic industries. However, its low solubility in aqueous medium and environmental instability limit its dosage. In this paper, we report the preparation of α-tocopherol loaded nanoparticles (TOC-NP) based on amphiphilic thermosensitive triblock copolymers PNIPAM-b-PCL-b-PNIPAM. The nanoparticles exhibited a core - shell structure, were positively charged and presented average diameters below 300 nm. TOC-NP presented controlled release of α-tocopherol at room temperature along 140h, and exhibited antioxidant properties in aqueous medium.

Original language	English
Pages (from-to)	304-312
Number of pages	9
Journal	Polimeros
Volume	26
Issue number	4
DOIs	https://doi.org/10.1590/0104-1428.2324
State	Published - 01 Oct 2016

Keywords

Polycaprolactone
Thermosensitive nanoparticles
Triblock copolymer
α-tocopherol

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abstract = "α-Tocopherol is the most bioavailable and active compound found in vitamin E with potential application in pharmaceutical, alimentary and cosmetic industries. However, its low solubility in aqueous medium and environmental instability limit its dosage. In this paper, we report the preparation of α-tocopherol loaded nanoparticles (TOC-NP) based on amphiphilic thermosensitive triblock copolymers PNIPAM-b-PCL-b-PNIPAM. The nanoparticles exhibited a core - shell structure, were positively charged and presented average diameters below 300 nm. TOC-NP presented controlled release of α-tocopherol at room temperature along 140h, and exhibited antioxidant properties in aqueous medium.",

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AU - Vera, Ricardo

AU - Perez, Leon Dario

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N2 - α-Tocopherol is the most bioavailable and active compound found in vitamin E with potential application in pharmaceutical, alimentary and cosmetic industries. However, its low solubility in aqueous medium and environmental instability limit its dosage. In this paper, we report the preparation of α-tocopherol loaded nanoparticles (TOC-NP) based on amphiphilic thermosensitive triblock copolymers PNIPAM-b-PCL-b-PNIPAM. The nanoparticles exhibited a core - shell structure, were positively charged and presented average diameters below 300 nm. TOC-NP presented controlled release of α-tocopherol at room temperature along 140h, and exhibited antioxidant properties in aqueous medium.

AB - α-Tocopherol is the most bioavailable and active compound found in vitamin E with potential application in pharmaceutical, alimentary and cosmetic industries. However, its low solubility in aqueous medium and environmental instability limit its dosage. In this paper, we report the preparation of α-tocopherol loaded nanoparticles (TOC-NP) based on amphiphilic thermosensitive triblock copolymers PNIPAM-b-PCL-b-PNIPAM. The nanoparticles exhibited a core - shell structure, were positively charged and presented average diameters below 300 nm. TOC-NP presented controlled release of α-tocopherol at room temperature along 140h, and exhibited antioxidant properties in aqueous medium.

KW - Polycaprolactone

KW - Thermosensitive nanoparticles

KW - Triblock copolymer

KW - α-tocopherol

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JO - Polimeros

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ER -

α-Tocopherol loaded thermosensitive polymer nanoparticles: Preparation, in vitro release and antioxidant properties

Abstract

Keywords

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