Determinacion y analisis in‐silico de asociaciones genomicas entre enfermedades raras: estrategia de identificacion de focos de susceptibilidad genomica.

Rare Diseases (RDs) involveseveralconditions from congenitalmalformations to inborn errors of                           metabolism. The diversity of genetics basis and molecular mechanisms for each RDs involve an                             ambiguous intervention in each disease. accordingly, it is necessary the implementation of new                           and diverse methods of exploration for a possible integration; it includes the development and                             application of new approaches, besides from different areas like bioinformatics.    In this project, the principal aim is the integration of genomic, molecular, and descriptive                             information deposit in public databases about RareDiseases, fortheidentification of patterns or                             regularities among those; thereforetheidentificationofpossiblefocusofgenomicsusceptibility.It                           includes structural and functional properties of the human genome.    For this project, weproposeto makedata mining, genomics comparisons, and theapplication of                               bioinformatics approaches mainly networksofassociationforanalysisofinformation.Wehopeby                           the network analysis, the identification of genomic susceptibility regions among several Rare                         Diseases.